Consumer medicine information

1. Why am I given Ceftazidime-AFT?

Ceftazidime-AFT contains the active ingredient Ceftazidime (as pentahydrate). Ceftazidime-AFT belongs to a group of medicines called cephalosporins. Ceftazidime-AFT is used to treat a wide range of infections caused by bacteria.
For more information, see Section 1. Why am I given Ceftazidime-AFT? in the full CMI.

2. What should I know before I am given Ceftazidime-AFT?

Do not use if you have ever had an allergic reaction to Ceftazidime-AFT or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
For more information, see Section 2. What should I know before I am given Ceftazidime-AFT? in the full CMI.

3. What if I am taking other medicines?

Some medicines may interfere with Ceftazidime-AFT and affect how it works.
A list of these medicines is in Section 3. What if I am taking other medicines? in the full CMI.

4. How is Ceftazidime-AFT given?

Ceftazidime-AFT will be administered as directed under the supervision of a doctor or nurse. You will not be expected to give yourself this medication.
More instructions can be found in Section 4. How is Ceftazidime-AFT given? in the full CMI.

5. What should I know while I am given Ceftazidime-AFT?

6. Are there any side effects?

Like all medicines, Ceftazidime-AFT can cause side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects. For more information, including what to do if you have any side effects, see Section 6. Are there any side effects? in the full CMI.

1 Name of Medicine

Ceftazidime (as pentahydrate).

2 Qualitative and Quantitative Composition

Ceftazidime-AFT is a cephalosporin antibiotic for use by injection only. It is supplied as a white or almost white crystalline powder in vials containing 1 g and 2 g ceftazidime (as pentahydrate) with sodium carbonate anhydrous (118 mg per gram of ceftazidime). On the addition of water for injections, Ceftazidime-AFT Injection dissolves with effervescence to produce a solution for injection.
Ceftazidime-AFT Injection contains approximately 52 mg (2.3 mEq) of sodium per gram of ceftazidime. 1.16 g ceftazidime pentahydrate is equivalent to 1 g ceftazidime free acid. For laboratory tests associated with ceftazidime administration, ceftazidime pentahydrate should be used.
For the full list of excipients, see Section 6.1.

3 Pharmaceutical Form

The drug product is white or almost white crystalline powder.
Powder for injection.

4 Clinical Particulars

4.9 Overdose

Overdosage can lead to neurological sequelae including encephalopathy, convulsions and coma. Ceftazidime can be removed by haemodialysis.
For information on the management of overdose, contact the Poisons Information Centre on 13 11 26 (Australia).

5 Pharmacological Properties

5.3 Preclinical Safety Data

Genotoxicity. No data available.
Carcinogenicity. No data available.

6 Pharmaceutical Particulars

6.7 Physicochemical Properties

Chemical structure.
https://stagingapi.mims.com/au/public/v2/images/fullchemgif/CSCEFPEN.gif Chemical name: (6R,7R)-7-[[(Z)-2-(2-aminothiazol-4-yl)-2-[(1-carboxy-1-methylethoxy) imino]acetyl]amino]-8-oxo-3-[(1-pyridinio) methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydrate.
Molecular formula: C₂₂H₂₂N₆O₇S₂.5H₂O.
Molecular weight: 636.6.
CAS number. 72558-82-8.

7 Medicine Schedule (Poisons Standard)

S4.

Summary Table of Changes

https://stagingapi.mims.com/au/public/v2/images/fulltablegif/CEFTAAST.gif