Consumer medicine information

1. Why am I using DOPAMINE JUNO?

DOPAMINE JUNO contains the active ingredient dopamine hydrochloride. Dopamine may be used to increase low blood pressure in people who have a severe infection, experienced a heart attack, lost blood during an accident, kidney failure or problems after surgery. Dopamine may be used to help the heart pump better in some people with congestive heart failure. For more information, see Section 1. Why am I using DOPAMINE JUNO? in the full CMI.

2. What should I know before I use DOPAMINE JUNO?

Do not use if you have ever had an allergic reaction to dopamine or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
For more information, see Section 2. What should I know before I use DOPAMINE JUNO? in the full CMI.

3. What if I am taking other medicines?

Some medicines may interfere with dopamine and affect how it works.
A list of these medicines is in Section 3. What if I am taking other medicines? in the full CMI.

4. How do I use DOPAMINE JUNO?

• Your doctor will decide the appropriate dose for you.

• A doctor or nurse will usually prepare and administer the injection or infusion.

• Follow all instructions given to you by your doctor and pharmacist.

5. What should I know while using DOPAMINE JUNO?

6. Are there any side effects?

Dopamine may cause dizziness, nausea, vomiting, headache, anxiety, cold or tingling feet, chest pain, irregular or rapid heart beat, or difficulty breathing.
For more information, including what to do if you have any side effects, see Section 6. Are there any side effects? in the full CMI.

Boxed Warnings

Dopamine is a potent drug. It must be diluted before administration. Do not add to alkaline solutions such as sodium bicarbonate, as these inactivate dopamine.

1 Name of Medicine

Dopamine hydrochloride.

2 Qualitative and Quantitative Composition

Dopamine Juno is a sterile solution containing dopamine hydrochloride 200 milligram/5 mL.
The pH of the solution is between 2.5 and 5. It must be diluted before use.
Excipient with known effect. Potassium metabisulfite.
For the full list of excipients, see Section 6.1 List of Excipients.

3 Pharmaceutical Form

Concentrated injection for infusion.
Ampoules containing a clear colourless or pale yellow solution.

4 Clinical Particulars

4.9 Overdose

Symptoms. Excessive elevation of blood pressure and vasoconstriction could be expected from accidental overdose (see Section 4.8 Adverse Effects (Undesirable Effects)).
Treatment. In case of accidental overdose the rate of administration should be reduced or the infusion discontinued temporarily until the patient's condition stabilises. Since the duration of action of dopamine is quite short, no additional measures are usually necessary. If these measures fail to stabilise the patient's condition in a relatively short time, use of the short acting alpha adrenergic blocking agent, phentolamine, should be considered.
For information on the management of overdose, contact the Poisons Information Centre on 13 11 26 (Australia). In New Zealand, call 0800 764 766.

5 Pharmacological Properties

5.3 Preclinical Safety Data

Genotoxicity. The genotoxic potential of dopamine has not been evaluated.
Carcinogenicity. Long term studies in animals have not been performed to evaluate the carcinogenic potential of dopamine.

6 Pharmaceutical Particulars

6.7 Physicochemical Properties

Dopamine hydrochloride is a naturally occurring biochemical catecholamine precursor of noradrenaline and adrenaline. The chemical name of dopamine hydrochloride is 4-(2- aminoethyl) benzene-1,2-diol hydrochloride and has the chemical formula C₈H₁₁NO₂.HCl.
Dopamine hydrochloride is a white, odourless powder, freely soluble in water and soluble in alcohol. It is sensitive to light, alkalis, iron salts and oxidising agents.
Chemical structure. The chemical structure is:
https://stagingapi.mims.com/au/public/v2/images/fullchemgif/CSDOPHYD.gif MW 189.6.
CAS number. CAS 51-61-6.

7 Medicine Schedule (Poisons Standard)

Schedule 4 - Prescription Only Medicine.

Summary Table of Changes

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