Consumer medicine information

Nicabate Mini 1.5 mg Lozenges

Nicotine

BRAND INFORMATION

Brand name

Nicabate Mini Lozenges

Active ingredient

Nicotine

Schedule

Unscheduled

 

Consumer medicine information (CMI) leaflet

Please read this leaflet carefully before you start using Nicabate Mini 1.5 mg Lozenges.

What is in this leaflet?


This leaflet answers some common questions about NICABATE Minis. It does not contain all the available information.
It does not take the place of talking to your pharmacist or doctor.
All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks of you using NICABATE Minis against the benefits this medicine is expected to have for you.
If you have any concerns about using this medicine, ask your pharmacist or doctor.
Keep this information with the medicine. You may need to read it again.

What are NICABATE Minis used for?


NICABATE Minis are a stop smoking aid. They can help you stop smoking over a few months. You can also use them to help you stop smoking more gradually over a longer period of time.
They help you to give up smoking by replacing some of the nicotine you are used to getting from cigarettes. It is the nicotine in cigarettes that can make you physically addicted to them. This type of treatment is called Nicotine Replacement Therapy (NRT).
NICABATE Minis contain a nicotine resin and, when used, nicotine is released slowly from the resin and absorbed through the lining of the mouth. This medicine can reduce your urge to smoke by providing some of the nicotine previously inhaled from cigarettes and helps you resist cigarettes. You may feel the following withdrawal symptoms when you stop smoking; anger, irritability, frustration; anxiety; difficulty concentrating; restlessness; increased appetite and or weight gain; insomnia; depression. The nicotine in NICABATE Minis may help relieve some or many of these symptoms.
There are no health benefits to smoking. It is always better to give up smoking and using NRT can help. In general any possible side effects associated with NRT are far outweighed by the well-established dangers of continuing to smoke.
If possible, when giving up smoking, NICABATE Minis should be used with a stop smoking behavioural support programme such as the NICABATE Quit Smoking Support Programme.
NICABATE 1.5 mg Minis are suitable for smokers who smoke 20 cigarettes or less a day.
NICABATE 4 mg Minis are suitable for smokers who smoke more than 20 cigarettes a day.
Your pharmacist or doctor may have given you this medicine for another reason.
If you need more information ask your pharmacist or doctor.

Before you use NICABATE Minis

When you must not use them


You should not use NICABATE Minis if:
  • You are allergic to nicotine or any of the ingredients listed at the end of this leaflet.
  • You are a non-smoker.
  • You are under 12 years of age.

If you are in hospital because of a heart attack, severe heart rhythm disturbances or a stroke, you should try to quit smoking without using NRT unless your doctor tells you to use it. Once you are discharged from hospital, you may use NRT in consultation with your doctor.
If you have diabetes you should monitor your blood sugar levels more often than usual when starting NICABATE Minis as you may find your insulin or other medication requirements alter.
If you have had allergic reactions that involve swelling of the lips, face and throat (angioedema) or itchy skin rash (urticaria), using NRT can sometimes trigger this type of reaction.
If you have epilepsy or are taking medicine for seizures, you should not use NICABATE Minis unless your doctor has told you to.
Do not use NICABATE Minis if you are under 12 years of age.
The levels of nicotine in NRT are suitable for people who are giving up smoking but not for children under 12. Children are more likely to be affected by nicotine and it could cause severe toxicity which can be fatal. Make sure you keep nicotine containing products out of the reach and sight of children at all times.
Do not use the medicine after the expiry date (EXP) printed on the pack.
If you take it after the expiry has passed, it may not work as well.
Do not use NICABATE Minis if the packaging is torn or shows signs of tampering.
Do not use this medicine to treat any other complaint unless your doctor or pharmacist says it is safe.
Do not give this medicine to anyone else even if they have the same symptoms as you.

Before you start to use it


You must tell your pharmacist or doctor if:
  • You have an uncontrolled, overactive thyroid gland. Nicotine may make your symptoms worse.
  • You have a stomach or duodenal ulcer or inflammation of the oesophagus. Swallowing nicotine can make your symptoms worse. Some people have reported getting mouth ulcers. If your symptoms do get worse you should talk to your doctor and you might want to use a non-oral type of NRT such as patches.
  • You have heart or circulation problems including heart failure or stable angina or high blood pressure.
  • You have had a stroke.
  • You have any serious liver or kidney disease. You may be more prone to side effects.
  • You are a diabetic.
  • You have been diagnosed as having a tumour of the adrenal glands (phaeochromocytoma). Nicotine may make your symptoms worse.
  • You have any allergies to any other medicines.
  • You are pregnant or intend to become pregnant.
  • You are breastfeeding or planning to breastfeed.
  • You have ever experienced seizures.

If you have not told your pharmacist or doctor about any of the above, tell them before you use NICABATE Minis.
If you are pregnant or breastfeeding then you should try to quit smoking without the use of NICABATE Minis if possible. However it is better to stop smoking using NRT than to continue smoking.
If you are pregnant
Smoking during pregnancy has risks such as poor growth of your baby before birth, premature birth or still birth. Stopping smoking is the best way to improve both your health and that of your baby. The earlier you stop smoking, the better.
Ideally, if you are pregnant, you should stop smoking without using NRT. However, if you have tried and this hasn’t worked, NRT may be recommended to help you stop smoking. This is because it is better for your developing baby than if you carry on smoking. The decision to use NRT should be made as early on in your pregnancy as possible and you should aim to use it for only 2-3 months. Remember, the most important thing is to stop smoking.
Products that are taken intermittently, such as lozenges or Gum, are preferable to nicotine patches. However, patches may be preferred if you have nausea or sickness.
If you are breastfeeding
Tobacco smoke causes breathing difficulties and other problems in babies and children. If you need to use NRT to help you quit, the amount of nicotine your baby may receive is much smaller and less harmful than breathing in second hand smoke. Do not use patches if you are breastfeeding. You should use NRT products that are taken intermittently (e.g. Gum or lozenges rather than patches) and breastfeed just before you take the product. This allows as long a time as possible between NRT use and feeding and will help your baby to get the smallest amount of nicotine possible.

Using other medicines


Tell your pharmacist or doctor if you are using any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.
Stopping smoking, with or without nicotine replacement products such as NICABATE Minis may alter the absorption of some medicines. The doses of the other medicines that you are using may need to be changed.
Other medicines may be affected by NICABATE Minis or affect how well NICABATE Minis work.
Your pharmacist or doctor can tell you what to do if you are taking any of these medicines.
If you have not told your pharmacist or doctor about any of these things, tell him/her before you take any NICABATE Minis

How to use NICABATE Minis


During any attempt to give up smoking using NICABATE Minis, it is important that you make every effort to stop smoking completely. However, if you do smoke a cigarette while you are using NRT, you should continue your quit attempt. Talking to your pharmacist or doctor may help.
For some people, the use of more than one NRT product may help them to identify the combination most appropriate for their individual quit attempt.
NICABATE 1.5 mg Minis are suitable for smokers who smoke 20 cigarettes or less a day.
NICABATE 4 mg Minis are suitable for smokers who smoke more than 20 cigarettes a day.
One lozenge should be placed in the mouth and be allowed to dissolve to be effective. From time to time the lozenge should be moved from one side of the mouth to the other. The lozenge should not be chewed, sucked or swallowed whole.
You should not eat or drink while a lozenge is in your mouth as this may reduce the absorption of nicotine. Avoid drinking acidic beverages such as coffee, juices and fizzy drinks for 15 minutes before sucking the lozenge as this may also reduce the absorption of nicotine.

Adults (18 years and over)


For smokers who want to stop smoking abruptly.
NICABATE Minis should be used according to the following schedule:
Weeks 1 to 6
1 lozenge every 1 to 2 hours

Weeks 7 to 9
1 lozenge every 2 to 4 hours

Weeks 10 to 12
1 lozenge every 4 to 8 hours

To help you stay smoke free over the next 12 weeks, take 1 lozenge in situations where you are strongly tempted to smoke.
Do not use more than 1 NICABATE Mini at a time and do not use more than 15 of the 4 mg NICABATE Minis or 20 of the 1.5 mg NICABATE Minis per day during weeks 1 to 6.
Do not use more than 1 NICABATE Mini per hour.
Adults aged 18 years and over should use at least nine NICABATE Minis a day for the first 6 weeks.
For adult smokers who want to stop over several months.
Use a lozenge whenever you have a strong urge to smoke instead of smoking a cigarette. Do not use more than 15 of the 4 mg NICABATE Minis a day or 20 of the 1.5 mg NICABATE Minis a day.
Do not use more than 1 NICABATE Mini per hour.
When you have reduced the number of cigarettes you smoke each day to a level you feel you can quit completely then use the schedule in the section above for smokers who want to quit smoking abruptly
If you have not reduced the number of cigarettes you smoke each day after 6 weeks, then see your pharmacist or doctor.
If you still need to use NICABATE Minis on a regular basis 6 months after the start of treatment and haven’t started a permanent quit attempt, you should seek help and advice from your pharmacist or doctor.

Using NICABATE combination therapy


Combination therapy can be used by smokers who have been unsuccessful giving up smoking when they have used just one type of NRT.
Do not use in young people aged 12 to 17 years.
If you want to use NICABATE Patches together with NICABATE 2 mg Gum, 2 mg Lozenges or 1.5 mg Minis, you should start with the 21 mg patch and you should use at least 4 pieces of Gum, Lozenges or Minis a day. Most people use 4 to 5 pieces a day. Do not use more than 12 pieces of Gum, Lozenges or Minis a day when using in addition to the patch.
If you are using NICABATE Patches together with Gum, Lozenges or Minis, the combination treatment should be used for 12 weeks. After this time you should begin weaning yourself off NRT. You can do this by:
1. Using the 14 mg patch for 2 weeks and then the 7 mg patch for 2 weeks while continuing to take the same number of NICABATE Minis you routinely use. Once you are not using any patches, you can gradually reduce the number of Lozenges, Minis or pieces of Gum until you are not using any.
OR
2. Stop using the 21 mg patch and then gradually reduce the number of Lozenges, Minis or pieces of Gum you are using.

Use in adolescents (12-17 years)


Young people aged 12 to 17 years old should only use NICABATE Minis for 10 weeks in total. If you think you may need to use NICABATE Minis for longer than 10 weeks, talk to your pharmacist or doctor.
NRT should only be used by those aged 12 to 17 years if a counselling programme is used at the same time. NRT is not likely to work in this age group if there is no counselling with it.

Use in children


Children under 12 years of age should not use NICABATE Minis.

How long to use it


Adults (over 18 years): NICABATE Minis should not be used after 9 months. If you find it difficult to give up NICABATE Minis or you are worried that you may start smoking again than speak to your pharmacist or doctor.
To give you the best chance for success, it is important you complete the step down programme in full.
This is because the urge to smoke and withdrawal symptoms can occur for weeks after stopping smoking.
Young people aged 12 to 17 years old should only use NICABATE Minis for 10 weeks in total (see Use in adolescents (12-17 years) above).
If you do start smoking again, you may want to talk to your pharmacist about how to get the best results from further courses of NICABATE Minis.
The directions given to you by your pharmacist or doctor may be different from the information in this leaflet. If you are unsure how to use this medicine, ask your pharmacist or doctor for advice.

If you use too much (Overdose)


If you smoke or use any other nicotine containing product while you are using NICABATE Minis, you may suffer an overdose of nicotine. However, if used correctly, nicotine overdose is unlikely.
Symptoms of nicotine overdosage include:

  • Headache
  • Dizziness
  • Stomach upset
  • Drooling
  • Vomiting
  • Diarrhoea
  • Cold sweat
  • Blurred vision
  • Hearing distortion
  • Confusion
  • Weakness
  • Fainting

If it is a large overdose, you may collapse and experience breathing difficulty.
Immediately telephone your doctor or Poisons Information Centre (Australia telephone 13 11 26, New Zealand telephone 0800 764 766) for advice or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else may have used too many NICABATE Minis.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Keep telephone numbers of these places handy.
NICABATE Minis are not suitable for children under 12 or for non-smokers. They may develop signs of nicotine overdose including headache, sickness, stomach pains and diarrhoea. Even small amounts of nicotine can be dangerous to children. If you think a child has used any NICABATE Minis, you must contact a doctor immediately.

While you are using NICABATE Minis

Things you must do


Use NICABATE Minis exactly as your pharmacist or doctor has told you to.
Tell all your doctors, dentists and pharmacists that you are using NICABATE Minis.
Tell your doctor or pharmacist if you become pregnant while using NICABATE Minis.

Side Effects


Tell your doctor or pharmacist as soon as possible if you do not feel well while taking NICABATE Minis.
NICABATE Minis help most people but they may have unwanted side effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Stopping smoking itself can cause some symptoms such as dizziness, headache, sleep disturbance, cough and cold-like symptoms. Symptoms such as depression, irritability, anxiety and insomnia may also be related to withdrawal symptoms associated with giving up smoking.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your pharmacist or doctor if you notice any of the following and they worry you:

  • Sore or swollen throat
  • Slightly sore or irritated mouth or tongue
  • Nausea
  • Hiccups
  • Stomach upsets
  • Vomiting
  • Diarrhoea
  • Indigestion/heartburn
  • Flatulence
  • Constipation
  • Dry mouth
  • Insomnia
  • Cough
  • Excess saliva
  • Dizziness
  • Headache
  • Palpitations (feeling your heart beat)

These are the more common side effects of NICABATE Minis. Mostly these are mild and short-lived. You may experience these side effects as you decrease the number of lozenges that you use.
If any of the following happen, stop using NICABATE Minis and tell your doctor immediately or go to accident and emergency at your nearest hospital:
  • Fast or very irregular heartbeat
  • Severe allergic reaction, symptoms of which include sudden wheeziness or tightness of the chest, rash and feeling faint.

These are very serious side effects. You may need urgent medical attention or hospitalisation.
Other side effects not listed above may also occur in some people. Tell your pharmacist or doctor if you notice anything else that is making you feel unwell.
Do not be alarmed by this list of possible side effects. You may not experience any of them.
Transferred dependence
Some people worry that they will quit smoking but become dependent on NICABATE Minis. This is very rare and, if it did happen, it is less harmful to you than continuing to smoke and an easier habit to break.

After using NICABATE Minis

Storage


Keep your NICABATE Minis in their container until it is time to use them.
If you keep the lozenges out of their container, they will not keep well.
Keep NICABATE Minis in a cool dry place
Heat and dampness can destroy some medicines. Do not leave NICABATE Minis in the car on hot days.
Store Mint lozenges below 30°C
Do not store NICABATE Minis or any other medicine in the bathroom or near a sink. Keep NICABATE Minis where children and pets cannot reach them.
A locked cupboard at least one and a half metres above the ground is a good place to store medicines.

Disposal


If your pharmacist or doctor tells you to stop using NICABATE Minis, ask your pharmacist what to do with any lozenges that are left over.
This is not all the information that is available on NICABATE Minis. If you have any more questions or are not sure about anything, ask your pharmacist or doctor.

Product Description


NICABATE Minis come in two strengths.
Active ingredient
Each NICABATE Minis lozenge contains either 1.5 mg or 4 mg of nicotine in the form of a resin complex called nicotine polacrilex. Nicotine polacrilex is also known as nicotine resinate.
Other ingredients:

  • Mannitol
  • Sodium alginate
  • Xanthan gum
  • Potassium bicarbonate
  • Polacrilin
  • Calcium polycarbophil
  • Sodium carbonate anhydrous
  • Magnesium stearate
  • Acesulfame potassium
  • Flavours
  • Water purified

Each strength comes in a container containing 20 lozenges.

Manufactured by


GlaxoSmithKline Consumer Healthcare
82 Hughes Avenue
ERMINGTON NSW 2115
ACN: 008 399 415
NICABATE Minis have the following Australian Registration numbers for:
Mint flavoured:
  • AUST R 156603 (1.5 mg)
  • AUST R 156604 (4 mg)

Date of preparation: March 2019
NICABATE and the MINIs device are trade mark of the GlaxoSmithKline group of companies.
Free NICABATE Quit Smoking Support Programme
Stopping smoking is a major decision that marks a turning point in your life. We are pleased that you have chosen to use NICABATE to help you quit.
Becoming an ex-smoker is not just about overcoming the cravings and urges for a cigarette, it is also about modifying your lifestyle to overcome the habits of smoking, like having a cigarette with your coffee or on the phone.
With NICABATE you don’t have to go it alone. Using NICABATE Minis will help you reduce the cravings for a cigarette and by joining our free stop smoking programme you can also receive help with the behavioural aspects of quitting.
This programme is FREE to anyone who has bought NICABATE. It is a programme designed to help you break the behavioural aspects of your smoking habit.
To join the programme, go to www.NICABATE.com.au

BRAND INFORMATION

Brand name

Nicabate Mini Lozenges

Active ingredient

Nicotine

Schedule

Unscheduled

 

1 Name of Medicine

Nicotine.

2 Qualitative and Quantitative Composition

Active ingredient. Nicotine.
Nicotine 1.5 mg lozenge.
Nicotine 4 mg lozenge.
Excipients. For the full list of excipients, see Section 6.1 List of Excipients.

3 Pharmaceutical Form

Nicabate Mini Lozenges nicotine 1.5 mg mint flavour lozenges. White to off white oval tablet with convex surfaces; one surface bearing a debossed "L" logo.
Nicabate Mini Lozenges nicotine 4 mg mint flavour lozenges. White to off white oval tablet with convex surfaces; one surface bearing a debossed "F" logo.

4 Clinical Particulars

4.9 Overdose

Nicotine doses that are tolerated by adult smokers during treatment may produce severe symptoms of poisoning in small children and may be fatal.
Signs and symptoms of an overdose from nicotine mini lozenges would be expected to be the same as those of acute nicotine poisoning, including pallor, cold sweat, salivation, nausea, vomiting, abdominal pain, diarrhoea, headache, dizziness, disturbed hearing and vision, tremor, mental confusion and weakness.
Prostration, hypotension, respiratory failure and convulsions may ensue with large overdoses.
Treatment of overdose. For information on the management of overdose, contact the Poison Information Centre on 13 11 26 (Australia).
All nicotine intake should stop immediately and the patient should be treated symptomatically. Activated charcoal may reduce absorption of the medicine if given within one or two hours after ingestion. In patients who are not fully conscious or have impaired gag reflex, consideration should be given to administering activated charcoal via a nasogastric tube, once the airway is protected.

5 Pharmacological Properties

Nicotine, the chief alkaloid in tobacco products, binds stereoselectively to acetylcholine receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions and in the brain. Two types of central nervous system effects are believed to be the basis of nicotine's positively reinforcing properties. A stimulating effect exerted mainly in the cortex via the locus ceruleus, produces increased alertness and cognitive performance. A "reward" effect via the "pleasure system" in the brain is exerted in the limbic system. At low doses the stimulant effects predominate, while at high doses the reward effects predominate. Intermittent intravenous administration of nicotine activates neurohormonal pathways, releasing acetylcholine, noradrenaline, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.

5.3 Preclinical Safety Data

The general toxicity of nicotine is well known and taken into account in the recommended posology. Nicotine was not mutagenic in appropriate assays. The results of carcinogenicity assays did not provide any clear evidence of a tumorigenic effect of nicotine. In studies in pregnant animals, nicotine showed maternal toxicity and consequential mild foetal toxicity. Additional effects included pre- and postnatal growth retardation and delays and changes in postnatal CNS development.
Effects were only noted following exposure to nicotine at levels in excess of those which will result from recommended use of Nicabate Mini Lozenges. Effects on fertility have not been established.
Comparison of the systemic exposure necessary to elicit these adverse responses from preclinical test systems with that associated with the recommended use of Nicabate Mini Lozenges indicate that the potential risk is low and outweighed by the demonstrable benefit of nicotine therapy in smoking cessation. However, Nicabate Mini Lozenges should only be used by pregnant women on medical advice if other forms of treatment have failed.
Genotoxicity. Nicotine and cotinine were not mutagenic in the Ames Salmonella test. Nicotine induced repairable DNA damage in an E. coli test system. Nicotine was shown to be genotoxic in a test system using Chinese hamster ovary cells.
Carcinogenicity. Nicotine itself does not appear to be a carcinogen in laboratory animals. However, nicotine and its metabolites increased the incidence of tumours in the cheek pouches of hamsters and forestomach of F344 rats, respectively, when given in combination with tumour initiators. One study, which could not be replicated, suggested that cotinine, the primary metabolite of nicotine, may cause lymphoreticular sarcoma in the large intestine in rats.

6 Pharmaceutical Particulars

6.7 Physicochemical Properties

Chemical structure.
https://stagingapi.mims.com/au/public/v2/images/fullchemgif/CSNICOTE.gif CAS number. 54-11-5.

7 Medicine Schedule (Poisons Standard)

Unscheduled.

Summary Table of Changes

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