Consumer medicine information

Olmesartan - MYL

Olmesartan medoxomil

BRAND INFORMATION

Brand name

Olmesartan-MYL

Active ingredient

Olmesartan medoxomil

Schedule

S4

 

Consumer medicine information (CMI) leaflet

Please read this leaflet carefully before you start using Olmesartan - MYL.

What is in this leaflet

This leaflet answers some common questions about OLMESARTAN - MYL.

It does not contain all the available information.

It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of you taking OLMESARTAN - MYL against the benefits he/she expects it will have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with your OLMESARTAN - MYL tablets or suspension. You may need to read it again.

What OLMESARTAN - MYL is used for

OLMESARTAN - MYL is used to treat high blood pressure which is sometimes called hypertension.

Everyone has blood pressure. This pressure helps push blood all around your body. Your blood pressure changes at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed.

There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, including stroke, heart disease and kidney failure.

How OLMESARTAN - MYL works

OLMESARTAN - MYL belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which causes blood vessels to tighten. OLMESARTAN - MYL blocks the action of angiotensin-II and therefore relaxes your blood vessels. This helps lower your blood pressure.

Your doctor may have prescribed OLMESARTAN - MYL for another reason. Ask your doctor if you have any questions about why OLMESARTAN - MYL has been prescribed for you.

OLMESARTAN - MYL is not addictive.

This medicine is available only with a doctor's prescription.

Before you take OLMESARTAN - MYL

When you must not take it

Do not take OLMESARTAN - MYL if:

  • you have serious problems with your kidneys
  • you have serious problems with your liver
  • you have diabetes and are taking a medicine called aliskiren to reduce blood pressure
  • you have an allergy to OLMESARTAN - MYL or any of the ingredients listed at the end of this leaflet
    Symptoms of an allergic reaction to OLMESARTAN - MYL may include skin rash, itchiness, shortness of breath, swelling of the face, lips or tongue, muscle pain or tenderness or joint pain.

Do not take OLMESARTAN - MYL if you are pregnant or breastfeeding. OLMESARTAN - MYL may enter your womb or it may pass into the breast milk and there is the possibility that your baby may be affected.

If pregnancy is discovered OLMESARTAN - MYL should be discontinued as soon as possible.

Do not take OLMESARTAN - MYL after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.

If you are not sure whether you should start taking OLMESARTAN - MYL, talk to your doctor.

Before you start to take it

Tell your doctor if you have allergies to:

  • any other medicines
  • any other substances, such as foods, preservatives or dyes.

Tell your doctor if you have or have had any medical conditions, especially the following:

  • kidney problems
  • liver problems
  • heart problems
  • excessive vomiting or diarrhoea recently
  • high levels of potassium in your blood
  • problems with your adrenal glands (small glands above the kidneys).

You must also tell your doctor if you:

  • are following a very low salt diet
  • you are or intend to become pregnant or plan to breastfeed.
  • you are taking potassium supplements, potassium-sparing agents, potassium-containing salt substitutes or other medicines that may increase serum potassium (e.g., trimethoprim-containing products)

If you have not told your doctor about any of the above, tell him/her before you start taking OLMESARTAN - MYL.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and OLMESARTAN - MYL may interfere with each other. These include:

  • other medicines used to treat high blood pressure
  • other diuretics, also known as fluid or water tablets
  • non-steroidal anti-inflammatory drugs (NSAIDs) or COX-2 inhibitors, medicines used to relieve pain, swelling and other symptoms of inflammation, including arthritis
  • potassium supplements or potassium-containing salt substitutes
  • other medicines that may increase serum potassium (e.g., trimethoprim-containing products)
  • lithium, a medicine used to treat mood swings and some types of depression
  • any medicines that contain aliskiren
  • any medicines that contain colesevelam.

These medicines may be affected by OLMESARTAN - MYL, or may affect how well it works. You may need different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.

In general, OLMESARTAN - MYL has been shown not to interfere with other medicines. However, it is important to tell your doctor and pharmacist about any medicines you are taking or plan to take.

Use in children

The safety and effectiveness of OLMESARTAN - MYL in children aged less than 1 year has not been established.

How to take OLMESARTAN - MYL

Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet.

If you have been prescribed OLMESARTAN - MYL suspension, your pharmacist will prepare this for you.

Your doctor or pharmacist will tell you which OLMESARTAN - MYL tablet or how much OLMESARTAN - MYL suspension you will need to take each day. This depends on your condition and whether or not you are taking any other medicines.

If you do not understand the instructions on the box or the suspension bottle, ask your doctor or pharmacist for help.

How much to take

Tablets:
For most adult patients, the usual starting dose of OLMESARTAN - MYL is 20 mg once a day. The dose may need to be increased to OLMESARTAN - MYL 40 mg once a day if necessary.

Suspension:
Follow the instructions given by your doctor or pharmacist.

Do not give OLMESARTAN - MYL suspension to children under 1 year of age.

For children 6-18 years (weighing 35kg or more):
One OLMESARTAN - MYL 20mg tablet once daily, or 10 mL of the 2 mg/mL suspension.

For children 6-18 years (weighing less than 35 kg):
5 mL of the 2 mg/mL suspension.

For children 1-5 years (weighing 5kg or more):
The dose will vary depending on your child's weight.

How to take it

Tablets:
Swallow OLMESARTAN - MYL whole with a full glass of water.
Do not chew the tablets.

Suspension:
Shake the bottle and then using either a medicine measure or a dosing syringe give the required volume to your child.

When to take it

Take OLMESARTAN - MYL at about the same time each day, with or without food. Taking OLMESARTAN - MYL at the same time each day will have the best effect. It will also help you remember when to take OLMESARTAN - MYL. It does not matter whether you take it with or without food.

How long to take it

OLMESARTAN - MYL helps control your condition, but does not cure it. Therefore you must take OLMESARTAN - MYL every day. Continue taking your medicine for as long as your doctor tells you.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take it as soon as you remember and then go back to taking your medicine as you would normally.

Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.

If you are not sure what to do, ask your doctor or pharmacist.

If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or the Australian Poisons Information Centre (telephone 13 11 26) or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much OLMESARTAN - MYL. Do this even if there are no signs of discomfort or poisoning.

Keep telephone numbers for these places handy.

If you take too much OLMESARTAN - MYL, you may feel light-headed, dizzy or you may faint. You may also have a fast heartbeat.

While you are using OLMESARTAN - MYL

Things you must do

If you are about to be started on any new medicine, tell your doctor, dentist or pharmacist that you are taking OLMESARTAN - MYL.

Make sure you drink enough water during exercise and hot weather when you are taking OLMESARTAN - MYL, especially if you sweat a lot. If you do not drink enough water while taking OLMESARTAN - MYL, you may feel faint, light-headed or sick. This is because your blood pressure is dropping suddenly. If you continue to feel unwell, tell your doctor.

If you have excess vomiting and/or diarrhoea while taking OLMESARTAN - MYL, tell your doctor. You may lose too much water and salt and your blood pressure may drop too much.

If you feel light-headed or dizzy after taking your first dose of OLMESARTAN - MYL, or when your dose is increased, tell your doctor immediately.

If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking OLMESARTAN - MYL. Your blood pressure may drop suddenly.

If you become pregnant while taking OLMESARTAN - MYL, tell your doctor immediately.

If you are about to have any blood tests, tell your doctor that you are taking OLMESARTAN - MYL. OLMESARTAN - MYL may interfere with the results of some tests.

Have your blood pressure checked when your doctor says, to make sure OLMESARTAN - MYL is working.

Go to your doctor regularly for a check-up. Your doctor may occasionally do a blood test to check your potassium levels and see how your kidneys are working.

Things you must not do

Do not give OLMESARTAN - MYL to anyone else, even if they have the same condition as you.

Do not take OLMESARTAN - MYL to treat any other complaints unless your doctor or pharmacist tells you to.

Do not stop taking OLMESARTAN - MYL, or lower the dosage, without checking with your doctor.

Things to be careful of

If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly. Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor.

Be careful driving or operating machinery until you know how OLMESARTAN - MYL affects you. As with other medicines in this class, OLMESARTAN - MYL may cause dizziness, light-headedness or tiredness in some people. Make sure you know how you react to OLMESARTAN - MYL before you drive a car, operate machinery, or do anything else that could be dangerous if you are dizzy or light-headed. If this occurs do not drive. If you drink alcohol, dizziness or light-headedness may be worse.

Things that would be helpful for your blood pressure

Some self help measures suggested below may help your condition. Talk to your doctor or pharmacist about these measures and for more information.

  • Alcohol - your doctor may advise you to limit your alcohol intake.
  • Weight - your doctor may suggest losing some weight to help lower your blood pressure and help lessen the amount of work your heart has to do. Some people may need a dietician's help to lose weight.
  • Diet - eat a healthy diet which includes plenty of fresh vegetables, fruit, bread, cereals and fish.
    Also eat less fat and sugar (especially saturated fat) which includes sausages, fatty meats, full cream dairy products, biscuits, cakes, pastries, chocolates, chips and coconut. Monounsaturated and polyunsaturated fats from olive oil, canola oil, avocado and nuts are beneficial in small quantities.
  • Salt - your doctor may advise you to watch the amount of salt in your diet. To reduce your salt intake you should avoid using salt in cooking or at the table and avoid cooked or processed foods containing high sodium (salt) levels.
  • Exercise - regular exercise, maintained over the long term, helps to reduce blood pressure and helps get the heart fitter. Regular exercise also improves your blood cholesterol levels, helps reduce your weight and stress levels, and improves your sleep, mood and ability to concentrate. However, it is important not to overdo it. Walking is good exercise, but try to find a route that is reasonably flat. Before starting any exercise, ask your doctor about the best kind of programme for you.
  • Smoking - your doctor may advise you to stop smoking or at least cut down. There are enormous benefits to be gained from giving up smoking. There are many professionals, organisations and strategies to help you quit. Ask your doctor or pharmacist for further information and advice.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking OLMESARTAN - MYL.

OLMESARTAN - MYL helps most people with high blood pressure, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

If you are over 65 years of age you may have an increased chance of getting side effects.

Ask your doctor or pharmacist to answer any questions you may have.

Following is a list of possible side effects. Do not be alarmed by this list. You may not experience any of them.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

  • feeling light-headed, dizzy or faint
  • cough
  • headache
  • feeling sick (nausea) or vomiting
  • stomach pain
  • diarrhoea
  • an uncomfortable feeling in the stomach
  • unusual tiredness or weakness, fatigue
  • 'flu-like' symptoms
  • runny or blocked nose, or sneezing
  • bronchitis
  • sore throat and discomfort when swallowing (pharyngitis)
  • swelling of the hands, feet or ankles
  • back pain
  • urinary tract infection.

These are common side effects. They are generally mild.

Tell your doctor as soon as possible if you notice any of the following:

  • skin rash or itchiness
  • aching, tender or weak muscles not caused by exercise
  • painful joints
  • fast heart beat
  • shortness of breath or tightness in the chest
  • swelling of the hands, feet or ankles
  • yellowing of the whites of the eyes, dark urine and itching of the skin.
  • symptoms that may indicate high potassium levels in the blood, such as nausea, diarrhoea, muscle weakness, change in heart rhythm.

These may be serious side effects. You may need medical attention. Serious side effects are rare.

If any of the following happen, stop taking OLMESARTAN - MYL and either tell your doctor immediately or go to Accident and Emergency at your nearest hospital:

  • swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing
  • chest pain.

These are very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are very rare.

Other side effects not listed above may occur in some patients. Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

After using OLMESARTAN - MYL

Storage

Tablets:

Keep your tablets in the box until it is time to take them. If you take the tablets out of the box they will not keep well.

Keep your tablets in a cool dry place where the temperature stays below 25°C.

Suspension:

Keep the suspension in the bottle until it is time to take it.

Keep the suspension in the refrigerator where the temperature stays between 2 to 8°C.

Do not store OLMESARTAN - MYL or any other medicine in the bathroom or near a sink.

Do not leave it on a windowsill or in the car on hot days. Heat and dampness can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Disposal

If your doctor or pharmacist tells you to stop taking OLMESARTAN - MYL or the tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.

Product description

What it looks like

OLMESARTAN - MYL tablets come in two strengths and each has a different appearance:

  • OLMESARTAN - MYL 20 mg - White, circular film coated tablet with characteristic odour approximately 8.5 mm in diameter, with C14 embossed on one side
  • OLMESARTAN - MYL 40 mg - White, oval film coated tablet with characteristic odour approximately 15 x 7 mm in size, with C15 embossed on one side.

A box of OLMESARTAN - MYL contains 10 or 30 tablets.

OLMESARTAN - MYL suspension is a pale reddish-white suspension.

Ingredients

Active ingredients:

  • OLMESARTAN - MYL 20 mg tablet - 20 mg olmesartan medoxomil per tablet
  • OLMESARTAN - MYL 40 mg tablet - 40 mg olmesartan medoxomil per tablet.
  • OLMESARTAN - MYL suspension - 2mg/mL olmesartan medoxomil

Other ingredients:

OLMESARTAN - MYL tablets:

  • microcrystalline cellulose
  • low-substituted hydroxypropylcellulose
  • lactose
  • hydroxypropylcellulose
  • magnesium stearate
  • Opadry OY-S-38956 that contains titanium dioxide, talc and hydroxypropylmethylcellulose.

OLMESARTAN - MYL tablets do not contain sucrose, tartrazine or any other azo dyes.

OLMESARTAN - MYL suspension:

  • purified water
  • citric acid
  • flavouring
  • glycerin
  • methylparaben
  • potassium sorbate
  • sodium phosphate
  • sorbitol
  • sucrose
  • calcium sulfate
  • carrageenan
  • dimethicone antifoam emulsion
  • microcrystalline cellulose
  • sodium carboxymethylcellulose
  • sodium phosphate monobasic
  • trisodium phosphate
  • xanthan gum

Supplier

OLMESARTAN - MYL is supplied in Australia by:

Organon Pharma Pty Ltd
Building A, 26 Talavera Road,
Macquarie Park NSW 2113

Australian Registration Numbers

  • OLMESARTAN - MYL 10 mg tablets are not currently registered in Australia
  • OLMESARTAN - MYL 20 mg tablets - AUST R 273571
  • OLMESARTAN - MYL 40 mg tablets - AUST R 273572

This leaflet was prepared August 2022.

Published by MIMS October 2022

BRAND INFORMATION

Brand name

Olmesartan-MYL

Active ingredient

Olmesartan medoxomil

Schedule

S4

 

1 Name of Medicine

Olmesartan medoxomil.

2 Qualitative and Quantitative Composition

Each film-coated tablet contains 20 mg olmesartan medoxomil.
Each film-coated tablet contains 40 mg olmesartan medoxomil.
Olmesartan medoxomil is a white to light yellowish-white powder or crystalline powder. It is practically insoluble in water and sparingly soluble in methanol.
List of excipients with known effect. Lactose (as monohydrate).
For the full list of excipients, see Section 6.1 List of Excipients.

3 Pharmaceutical Form

20 mg tablet. White, circular film-coated tablet with C14 embossed on one side.
40 mg tablet. White, oval film-coated tablet with C15 embossed on one side.

4 Clinical Particulars

4.9 Overdose

Only limited information is available regarding overdosage in humans. The most likely effect of overdosage is hypotension and tachycardia; bradycardia could be encountered if parasympathetic (vagal) stimulation occurs. In the event of overdosage, the patient should be carefully monitored and treatment should be symptomatic and supportive.
No information is available regarding the dialysability of olmesartan.
For information on the management of overdose, contact the Poisons Information Centre on 131126 (Australia).

5 Pharmacological Properties

5.3 Preclinical Safety Data

Genotoxicity. Both olmesartan medoxomil and olmesartan tested negative in the in vitro Syrian hamster embryo cell transformation assay and showed no evidence of genetic toxicity in the Ames (bacterial mutagenicity) test. However, both were shown to induce chromosomal aberrations in cultured cells in vitro (Chinese hamster lung) and tested positive for thymidine kinase mutations in the in vitro mouse lymphoma assay. Olmesartan medoxomil tested negative in vivo for mutations in the intestine and kidney of a mutagenic susceptible mouse (MutaMouse) and for clastogenicity in mouse bone marrow (micronucleus test) at oral doses of up to 2,000 mg/kg. Olmesartan not tested in this mouse model. On balance, the weight-of-evidence indicates that olmesartan medoxomil does not pose a genotoxic risk at clinically relevant doses.
Carcinogenicity. Olmesartan medoxomil was not carcinogenic when administered by dietary administration to rats for up to 2 years. The highest dose tested (2,000 mg/kg/day) corresponded to a relative systemic exposure to olmesartan that was about 30 times that anticipated at the maximum recommended human dose (MRHD) of 40 mg/day (based on AUC). Two carcinogenicity studies conducted in mice, a 6-month gavage study in the p53 knockout mouse and a 6-month dietary administration study in the Hras2 transgenic mouse, at doses of up to 1,000 mg/kg/day (about 11 times anticipated clinical exposure to olmesartan at the MRHD, based on AUC in Hras2), revealed no evidence of a carcinogenic effect of olmesartan medoxomil.

6 Pharmaceutical Particulars

6.7 Physicochemical Properties

Olmesartan-MYL (olmesartan medoxomil), a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.
Olmesartan medoxomil is described chemically as 2,3-dihydroxy-2- butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl] imidazole-5-carboxylate, cyclic 2,3-carbonate.
Its empirical formula is C29H30N6O6. Its molecular weight is 558.59.
Chemical structure. Its structural formula is:
https://stagingapi.mims.com/au/public/v2/images/fullchemgif/CSOLMMED.gif CAS number. 144689-63-4.

7 Medicine Schedule (Poisons Standard)

Prescription only medicine (S4).

Summary Table of Changes

https://stagingapi.mims.com/au/public/v2/images/fulltablegif/OLMMYLST.gif