Consumer medicine information

Ringer's Solution Intravenous Infusion

Sodium chloride + Potassium chloride + Calcium chloride dihydrate

BRAND INFORMATION

Brand name

Baxter Ringer's Solution

Active ingredient

Sodium chloride + Potassium chloride + Calcium chloride dihydrate

Schedule

Unscheduled

 

Consumer medicine information (CMI) leaflet

Please read this leaflet carefully before you start using Ringer's Solution Intravenous Infusion.

What is in this leaflet?

This leaflet answers some common questions about Ringer’s Solution IV Infusion. It does not contain all of the available information. All medicines have risks and benefits. Your doctor has weighed the risks of you using Ringer’s Solution IV Infusion against the benefit they expect it will have for you.

It does not take the place of talking to your doctor or pharmacist.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

What Ringer's Solution IV Infusion is used for

This medicine is used to replace and balance body fluid and mineral salts.

Before you are given Ringer’s Solution IV Infusion

The Ringer’s Solution IV Infusion should not be given to you if:

  • you have an allergy to any ingredient listed at the end of this leaflet;
  • you have fluid overload or are overhydrated;
  • you have swelling and ascitic cirrhosis (abnormal accumulation of fluid in the abdomen due to liver disease);
  • you have heart failure;
  • you have serious kidney problems where you are passing little or no urine;
  • you have too much potassium, sodium, calcium or chlorides in your blood that is not being corrected with medication;
  • you are taking digitalis (a heart medication);
  • the expiry date printed on the pack is overdue.

You must tell your doctor if you:

  • have heart problem;
  • have kidney problems including kidney stones;
  • are taking any other medicine including those you can buy without a prescription, in particular medicines for high blood pressure (diuretics, ACE inhibitors or ARAs), immunosuppressant medicines (tacrolimus or cyclosporin), carbenoxolone, corticosteroids or vitamin D
  • are pregnant and have ‘preeclampsia’ (a serious condition in pregnancy that causes high blood pressure)

How Ringer’s Solution IV Infusion is given

How much it is given:

Your doctor will decide how much Ringer’s Solution IV Infusion will be given to you, which depends on your need and condition. The medicine is given by a slow rate (drip) injection; therefore it should be given by using special equipment and attended by a health professional (doctor, trained nurse).

How it is given:

The Ringer’s Solution IV Infusion will be given at a slow rate of injection (drip) by your health professional. Usually, you will need to stay in a health institution (hospital, nursing home, etc.) but in some cases at home, as it requires a special medical equipment to deliver the medicine into your circulation. This delivery should be attended by a health professional. A cannula (administration needle) is placed in a vein by your doctor or nurse.

The infusion is for single use, and for one person only. Any unused portion must be discarded and not used later, either for you or anyone else.

Overdose

The doctor or nurse giving you the Ringer’s Solution IV Infusion has had experience in the use of this sort of medicine, so it is unlikely that you will be given an overdose. However, in case of an overdose, the infusion will be discontinued and another treatment may be needed. You may experience some of the effects listed under “Side Effects” below.

While you are given Ringer’s Solution IV Infusion

Discuss with your doctor the progress you have experienced after the treatment, whether any complication has occurred, especially during the first few days of therapy. Frequent clinical evaluation and laboratory tests may be required. As Ringer’s Solution IV Infusion is normally given in a hospital, your nurse provider will take records of the progress and unexpected reactions.

Side effects

As with any medicines, some side effects may occur. Undesirable side effects such as a build-up of fluid and swelling of the hands, ankles and feet may occur. Additionally, as with other preparations similar to Ringer’s Solution IV Infusion, pain, irritation, inflammation, swelling or abnormal clotting at the site of injection is also possible.

Always tell your doctor or nurse if you have any unexpected effects during or after receiving Ringer’s Solution IV Infusion.

More serious side effects may also occur such as chest pain, fast or slow heartbeat, or swelling of the face, lips or mouth causing breathing difficulties. If these occur, tell your health professional on duty immediately. These may be symptoms of a serious allergic reaction. Your health professional will take an appropriate action promptly, such as stopping the infusion.

Product descriptions

What Ringer’s Solution IV Infusion looks like

It is a clear, colourless solution filled in plastic bags.

What is in Ringer’s Solution IV Infusion?

The active components are Sodium Chloride, Potassium Chloride and Calcium Chloride, formulated and dissolved in water for injection. The bag pack sizes are included below:

AHB2304
Potassium Chloride (300mg/L), Sodium Chloride (8.6g/L), Calcium Chloride (330mg/L)
AUST R 19443
1000mL

How to store Ringers Solution IV Infusion
Ringer’s Solution IV Infusion will be stored in the pharmacy or the hospital ward. It is recommended that the product be stored below 30°C.

Where can you get more information?
You can get more information from your doctor or pharmacist.

Name and address of the sponsor
Baxter Healthcare Pty Ltd
1 Baxter Drive
Old Toongabbie NSW 2146

Date of preparation:
March 2014

Published by MIMS July 2019

BRAND INFORMATION

Brand name

Baxter Ringer's Solution

Active ingredient

Sodium chloride + Potassium chloride + Calcium chloride dihydrate

Schedule

Unscheduled

 

1 Name of Medicine

Sodium chloride, potassium chloride and calcium chloride dihydrate.

2 Qualitative and Quantitative Composition

The active ingredient in Baxter Ringer's Solution for Intravenous (IV) Infusion (Ringer's Solution) comprise sodium chloride (8.6 g/L), potassium chloride (0.3 g/L) and calcium chloride dihydrate (0.33 g/L) in water for injections.
Baxter Ringer's Solution is sterile and non-pyrogenic. There is no antimicrobial agent or buffer added. It is an isotonic intravenous solution with pH of 5.0 - 7.5 and an osmolality of 308 mOsm/kg.
For the full list of excipients, see Section 6.1 List of Excipients.

3 Pharmaceutical Form

Baxter Ringer's Solution is a clear colourless solution for Intravenous Infusion.

4 Clinical Particulars

4.9 Overdose

Excessive or too fast administration of Baxter Ringer's Solution can cause:
fluid and sodium overload with a risk of oedema (peripheral and/or pulmonary), particularly when renal sodium excretion is impaired. In such cases extra renal dialysis may be necessary;
hyperkalaemia, especially in patients with renal impairment. Symptoms include paresthesia of the extremities, muscle weakness, paralysis, cardiac arrhythmias, heart block, cardiac arrest, and mental confusion. Treatment of hyperkalaemia involves the administration of calcium, insulin (with glucose), sodium bicarbonate, exchange resins or dialysis;
hypercalcaemia: symptoms of hypercalcaemia may include anorexia, nausea, vomiting, constipation, abdominal pain, muscle weakness, mental disturbances, polydipsia, polyuria, nephrocalcinosis, renal calculi, and, in severe cases, cardiac arrhythmias and coma. Too rapid intravenous injection of calcium salts may also lead to many of the symptoms of hypercalcaemia as well as to a chalky taste, hot flushes, and peripheral vasodilatation. Mild asymptomatic hypercalcaemia will usually resolve on stopping administration of calcium and other contributory drugs such as vitamin D. If hypercalcaemia is severe, urgent treatment (such as loop diuretics, haemodialysis, calcitonin, bisphosphonates, trisodium edetate) is required;
hyperchloraemia;
a loss of bicarbonate with an acidifying effect.
When assessing an overdose, any additives in the solution must also be considered. When overdose is related to medicinal products added to the solution infused, the signs and symptoms of over infusion will be related to the nature of the additive being used.
The effects of an overdose may require immediate medical attention and treatment. Interventions include discontinuation of Baxter Ringer's Solution administration, dose reduction, and other measures as indicated for the specific clinical constellation.
The patient should be observed for the appropriate signs and symptoms related to the drug administered. The relevant symptomatic and supportive measures should be provided as necessary.
For information on the management of overdose, contact the Poisons Information Centre on 13 11 26 (Australia).

5 Pharmacological Properties

5.3 Preclinical Safety Data

Genotoxicity. The active ingredients potassium chloride, sodium chloride and calcium chloride are not mutagenic at physiological concentrations.
Carcinogenicity. The active ingredients potassium chloride, sodium chloride and calcium chloride are not carcinogenic at physiological concentrations.

6 Pharmaceutical Particulars

6.7 Physicochemical Properties

Sodium chloride. Molecular formula: NaCl.
Molecular Weight: 58.44.
Appearance: colourless or white crystal.
Solubility: freely soluble in water.
Potassium chloride. Molecular formula: KCl.
Molecular Weight: 74.55.
Appearance: colourless or white crystal.
Solubility: freely soluble in water.
Calcium chloride dihydrate. Molecular formula: CaCl2.2H2O.
Molecular Weight: 147.01.
Appearance: a white crystalline powder.
Solubility: hygroscopic, freely soluble in water.
CAS number. Sodium chloride. CAS No.: 7647-14-5.
Potassium chloride. CAS No.: 7447-40-7.
Calcium chloride dihydrate. CAS No.: 10035-04-8.

7 Medicine Schedule (Poisons Standard)

Unscheduled.

Summary Table of Changes

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