Consumer medicine information

1. Why am I using ZINNAT tablets?

ZINNAT tablets contains the active ingredient cefuroxime axetil. ZINNAT tablets is used to treat bacterial infections in your body including infections of ear, nose and throat, lungs or chest, urinary tract, skin and soft tissues. It is also used to treat sexually transmitted infections (urethritis and cervictis).
For more information, see Section 1. Why am I using ZINNAT tablets? in the full CMI.

2. What should I know before I use ZINNAT tablets?

Do not use if you have ever had an allergic reaction to ZINNAT or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
For more information, see Section 2. What should I know before I use ZINNAT tablets? in the full CMI.

3. What if I am taking other medicines?

Some medicines may interfere with ZINNAT tablets and affect how it works.
A list of these medicines is in Section 3. What if I am taking other medicines? in the full CMI.

4. How do I use ZINNAT tablets?

• The usual dose of ZINNAT is one 250 mg tablet twice a day for 7 to 10 days.

• Take your complete course of ZINNAT tablets as directed by your doctor or pharmacist.

5. What should I know while using ZINNAT tablets?

6. Are there any side effects?

Common side effects include headache, abdominal pain, dizziness, nausea or vomiting, mild diarrhoea, indigestion or wind, or dry mouth.
Serious side effects include skin rash, a widespread rash with blisters and skin peeling on much of the body surface, persistent diarrhoea, overgrowth of yeast in the body, or allergic reactions.
For more information, including what to do if you have any side effects, see Section 6. Are there any side effects? in the full CMI.

1 Name of Medicine

Cefuroxime axetil.

2 Qualitative and Quantitative Composition

Zinnat tablets 125 mg. Each tablet contains cefuroxime (as axetil) 125 mg.
Zinnat tablets 250 mg. Each tablet contains cefuroxime (as axetil) 250 mg.
For the full list of excipients, see Section 6.1 List of Excipients.

3 Pharmaceutical Form

Zinnat 125 mg and 250 mg tablets are present in blister packs.
Zinnat tablets 125 mg. White, film coated, capsule shaped, biconvex tablets engraved "GXES5" on one face and blank on the other.
Zinnat tablets 250 mg. White, film coated, capsule shaped, biconvex tablets engraved "GXES7" on one face and blank on the other.

4 Clinical Particulars

4.9 Overdose

Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.
Serum levels of cefuroxime can be reduced by haemodialysis.
For information on the management of overdose, contact the Poisons Information Centre on 13 11 26 (Australia).

5 Pharmacological Properties

5.3 Preclinical Safety Data

Preclinical safety data were either not assessed or not identified as part of the registration of this medicine.
Genotoxicity. No data available.
Carcinogenicity. No data available.

6 Pharmaceutical Particulars

6.7 Physicochemical Properties

Chemical structure. Cefuroxime axetil is the 1-(acetyloxy)ethyl ester of cefuroxime. Its chemical name is (RS)-1-hydroxyethyl(6R,7R)-7-[2-(2-furyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0]-oct-2-ene-2-carboxylate, 7²)-(Z)-(O-methyoxime), 1-acetate 3-carbamate. Its molecular formula is C₂₀H₂₂N₄O₁₀S, and it has a molecular weight of 510.48.
Cefuroxime axetil is in the amorphous form, and it has the following structural formula:
https://stagingapi.mims.com/au/public/v2/images/fullchemgif/CSCEFAXE.gif CAS number. 64544-07-6.

7 Medicine Schedule (Poisons Standard)

Schedule 4 - Prescription Only Medicine.

Summary Table of Changes

https://stagingapi.mims.com/au/public/v2/images/fulltablegif/ZINNATST.gif