Rheumatoid arthritis Practice Review – Accessible version of data in this report
Fig. 2 – Types of csDMARDs dispensed before starting a b/tsDMARD for RA
Percentage of patients starting b/tsDMARD treatment for RA (1 Jan 2018 to 31 Dec 2019) |
||||||
National |
NSW/ACT |
VIC/TAS |
QLD |
NT/SA |
WA |
|
MTX |
87 |
87 |
88 |
86 |
84 |
84 |
Leflunomide |
34 |
36 |
28 |
37 |
36 |
42 |
Sulfasalazine |
30 |
32 |
29 |
35 |
37 |
20 |
Hydroxychloroquine |
56 |
52 |
60 |
61 |
61 |
47 |
Fig. 3 – Types of MTX dispensed before starting b/tsDMARD for RA in 2017, 2018 or 2019
Percentage of patients starting b/tsDMARD treatment for RA (by year) |
|||
National |
2017 |
2018 |
2019 |
Oral MTX only |
47 |
50 |
38 |
Subcutaneous MTX only |
12 |
18 |
15 |
Oral and subcutaneous MTX |
24 |
21 |
38 |
No MTX |
18 |
11 |
9 |
NSW/ACT |
2017 |
2018 |
2019 |
Oral MTX only |
78 |
81 |
82 |
Subcutaneous MTX only |
2 |
1 |
1 |
Oral and subcutaneous MTX |
4 |
4 |
5 |
No MTX |
17 |
14 |
12 |
VIC/TAS |
2017 |
2018 |
2019 |
Oral MTX only |
77 |
80 |
79 |
Subcutaneous MTX only |
3 |
3 |
2 |
Oral and subcutaneous MTX |
5 |
5 |
7 |
No MTX |
15 |
12 |
12 |
QLD |
2017 |
2018 |
2019 |
Oral MTX only |
76 |
80 |
73 |
Subcutaneous MTX only |
3 |
2 |
2 |
Oral and subcutaneous MTX |
4 |
5 |
11 |
No MTX |
18 |
13 |
14 |
NT/SA |
2017 |
2018 |
2019 |
Oral MTX only |
69 |
71 |
70 |
Subcutaneous MTX only |
4 |
3 |
4 |
Oral and subcutaneous MTX |
6 |
9 |
12 |
No MTX |
20 |
18 |
15 |
WA |
2017 |
2018 |
2019 |
Oral MTX only |
80 |
75 |
77 |
Subcutaneous MTX only |
3 |
3 |
2 |
Oral and subcutaneous MTX |
3 |
4 |
6 |
No MTX |
14 |
18 |
14 |
Fig. 4 – Choice of first-line b/tsDMARD treatment for patients with RA
Percentage of patients starting b/tsDMARD treatment for RA (1 Jan 2018 to 31 Dec 2019) |
||||||
National |
NSW/ACT |
VIC/TAS |
QLD |
NT/SA |
WA |
|
Adalimumab |
24 |
25 |
25 |
21 |
26 |
21 |
Certolizumab |
5 |
5 |
6 |
4 |
4 |
3 |
Etanercept |
19 |
19 |
23 |
18 |
15 |
15 |
Golimumab |
16 |
16 |
12 |
20 |
15 |
21 |
Infliximab |
0 |
0 |
0 |
0 |
0 |
0 |
Baricitinib |
9 |
7 |
11 |
9 |
7 |
8 |
Tofacitinib |
16 |
16 |
12 |
17 |
21 |
23 |
Rituximab |
1 |
1 |
1 |
1 |
1 |
1 |
Abatacept |
4 |
4 |
5 |
4 |
5 |
3 |
Tocilizumab |
6 |
7 |
5 |
6 |
7 |
4 |
Fig. 5 – Number of unique patients dispensed prescriptions for b/tsDMARDs for RA over the years
National |
2016 |
2017 |
2018 |
2019 |
|
TNF inhibitor |
Adalimumab |
7681 |
8149 |
8580 |
8635 |
Certolizumab |
1416 |
1435 |
1744 |
2020 |
|
Etanercept |
6484 |
6724 |
7125 |
7018 |
|
Golimumab |
655 |
719 |
2151 |
2863 |
|
Infliximab |
325 |
318 |
305 |
296 |
|
JAK inhibitor |
Baricitinib |
0 |
0 |
875 |
3485 |
Tofacitinib |
3417 |
4415 |
5619 |
6211 |
|
B lymphocyte modulator |
Rituximab |
1114 |
1201 |
1184 |
1158 |
T lymphocyte modulator |
Abatacept |
3462 |
3290 |
2806 |
3274 |
IL-6 inhibitor |
Tocilizumab |
3302 |
4494 |
5132 |
5415 |
NSW/ACT |
2016 |
2017 |
2018 |
2019 |
|
TNF inhibitor |
Adalimumab |
2406 |
2573 |
2739 |
2782 |
Certolizumab |
443 |
458 |
555 |
684 |
|
Etanercept |
2319 |
2374 |
2452 |
2352 |
|
Golimumab |
204 |
219 |
623 |
849 |
|
Infliximab |
98 |
87 |
85 |
84 |
|
JAK inhibitor |
Baricitinib |
0 |
0 |
215 |
957 |
Tofacitinib |
1079 |
1357 |
1736 |
1980 |
|
B lymphocyte modulator |
Rituximab |
267 |
300 |
283 |
273 |
T lymphocyte modulator |
Abatacept |
1030 |
987 |
798 |
984 |
IL-6 inhibitor |
Tocilizumab |
1002 |
1424 |
1688 |
1797 |
VIC/TAS |
2016 |
2017 |
2018 |
2019 |
|
TNF inhibitor |
Adalimumab |
2436 |
2686 |
2827 |
2865 |
Certolizumab |
465 |
508 |
632 |
729 |
|
Etanercept |
1632 |
1826 |
2117 |
2185 |
|
Golimumab |
162 |
184 |
533 |
741 |
|
Infliximab |
79 |
87 |
73 |
72 |
|
JAK inhibitor |
Baricitinib |
0 |
0 |
347 |
1390 |
Tofacitinib |
1142 |
1500 |
1785 |
1780 |
|
B lymphocyte modulator |
Rituximab |
368 |
417 |
384 |
389 |
T lymphocyte modulator |
Abatacept |
943 |
910 |
839 |
1019 |
IL-6 inhibitor |
Tocilizumab |
930 |
1268 |
1432 |
1532 |
QLD |
2016 |
2017 |
2018 |
2019 |
|
TNF inhibitor |
Adalimumab |
1208 |
1222 |
1324 |
1312 |
Certolizumab |
289 |
254 |
290 |
317 |
|
Etanercept |
1004 |
1042 |
1089 |
1090 |
|
Golimumab |
156 |
165 |
500 |
627 |
|
Infliximab |
54 |
63 |
70 |
70 |
|
JAK inhibitor |
Baricitinib |
0 |
0 |
155 |
502 |
Tofacitinib |
682 |
863 |
1019 |
1096 |
|
B lymphocyte modulator |
Rituximab |
221 |
231 |
247 |
263 |
T lymphocyte modulator |
Abatacept |
586 |
567 |
468 |
531 |
IL-6 inhibitor |
Tocilizumab |
620 |
812 |
944 |
1028 |
NT/SA |
2016 |
2017 |
2018 |
2019 |
|
TNF inhibitor |
Adalimumab |
577 |
620 |
653 |
655 |
Certolizumab |
55 |
55 |
73 |
104 |
|
Etanercept |
485 |
473 |
473 |
479 |
|
Golimumab |
51 |
67 |
178 |
202 |
|
Infliximab |
22 |
30 |
30 |
28 |
|
JAK inhibitor |
Baricitinib |
0 |
0 |
31 |
210 |
Tofacitinib |
221 |
324 |
435 |
506 |
|
B lymphocyte modulator |
Rituximab |
67 |
73 |
69 |
66 |
T lymphocyte modulator |
Abatacept |
259 |
275 |
251 |
278 |
IL-6 inhibitor |
Tocilizumab |
268 |
376 |
438 |
422 |
WA |
2016 |
2017 |
2018 |
2019 |
|
TNF inhibitor |
Adalimumab |
1115 |
1106 |
1111 |
1073 |
Certolizumab |
171 |
170 |
199 |
193 |
|
Etanercept |
1072 |
1042 |
1019 |
941 |
|
Golimumab |
82 |
87 |
322 |
457 |
|
Infliximab |
72 |
51 |
48 |
43 |
|
JAK inhibitor |
Baricitinib |
0 |
0 |
127 |
427 |
Tofacitinib |
301 |
390 |
665 |
875 |
|
B lymphocyte modulator |
Rituximab |
193 |
183 |
201 |
172 |
T lymphocyte modulator |
Abatacept |
654 |
570 |
458 |
471 |
IL-6 inhibitor |
Tocilizumab |
498 |
640 |
661 |
666 |
Fig. 6 – Prescribing of glucocorticoids ≥ 6 months after starting b/tsDMARD treatment for RA
Percentage of patients who started b/tsDMARD treatment (1 Nov 2016 to 31 Oct 2018) |
||||||
National |
NSW/ACT |
VIC/TAS |
QLD |
NT/SA |
WA |
|
0 prescriptions |
50 |
52 |
43 |
53 |
58 |
55 |
1-2 prescriptions |
18 |
17 |
18 |
18 |
18 |
18 |
3-4 prescriptions |
7 |
7 |
8 |
7 |
7 |
9 |
≥ 5 prescriptions |
25 |
24 |
31 |
23 |
18 |
17 |
Fig. 7 – Prescribing of opioids for patients also prescribed b/tsDMARDs for RA
Percentage of patients dispensed b/tsDMARDs (1 Jan 2018 to 31 Dec 2019) |
||||||
National |
NSW/ACT |
VIC/TAS |
QLD |
NT/SA |
WA |
|
0 prescriptions |
53 |
56 |
53 |
49 |
48 |
52 |
1-5 prescriptions |
26 |
25 |
26 |
27 |
29 |
26 |
6-9 prescriptions |
5 |
4 |
4 |
5 |
6 |
5 |
≥ 10 prescriptions |
16 |
14 |
17 |
19 |
17 |
17 |